Lyme Disease is often misdiagnosed and quite misunderstood. All too often, patients from all corners of the country initially present to their primary care physicians complaining of a similar pattern of symptoms. The physician follows a conventional treatment plan within the standard of care he was trained in to help ameliorate one symptom or the other, but most patients fail to respond. Further misfortune can affect the patient by causing debilitation affecting their studies, their careers, and even their family lives. Lyme disease has become devastating for a large portion of patients who can no longer work at the capacity prior to their infection.Years of worsening symptoms can go by and several integrative therapies can be exhausted before some further investigation finally identifies the culprit.Lyme disease is very tricky, and most doctors struggle with the management of their affected patients. Most physicians do not immediately suspect the disease and do not understand that the symptoms cannot easily clear up after only 4 weeks of antibiotics. The bacteria, similar to that causing Syphilis (although not sexually transmitted), is difficult to eliminate. The culprit is a spirochete, a bacterium able to withstand extreme elements before it penetrates through cells, invading all tissues, particularly the central nervous system like the brain and the spinal cord. Once exposed to the standard tetracycline, the first-line antibiotic, the bacteria is able to hide or turn into a cyst-like form making it very difficult to kill. Most physicians will then turn to cephalosporins, another type of antibiotic, with no further improvement, leading to frustration from both the patient and the healthcare provider.The key is combining treatments, including pulsing antibiotics that kill all 4 cell types, with stem cell delivery and hormone optimization therapies. Pulsing antibiotics is also another effective treatment for those who are unable to tolerate multiple antibiotics.